Professor of Ob/Gyn at the University of Valencia; Senior Lecturer PT, BIDMC Harvard University; Adjunct Clinical Professor at Baylor College of Medicine; Invited Professor at University of California San Francisco and President of Carlos Simon Foundation.
His main clinical and scientific interest is in the understanding of the human embryonic implantation process, a critical process to the survival of the species, considering as key elements the embryo, the maternal endometrium, and the cross-communication between them.
His group identified the transcriptomic signature of human endometrial receptivity using microarray technology (PMID: 20619403) and its confirmation by single-cell RNA seq (PMID: 32929266). Clinical translation of this work resulted in the creation of the endometrial receptivity analysis (ERA) for the diagnosis of the personalized window of implantation. His team provided evidence of a decidualization defect in the endometrium of women with severe preeclampsia (PMC: 5635883), further discovering the footprint encoding this defect (PMC: 8553341). Also, they demonstrated that the human uterine cavity is not sterile, by identifying the existence of the endometrial microbiome (PMID: 27717732)) and its functional implications in pregnancy outcome (PMC: 8725275). Further, they investigated the existence and the functional proof of concept of human endometrial stem cells. Today, these findings are being translated to the first advanced cellular therapy of Asherman Syndrome ((PMID: 27005892)(EudraCT Number: 2016-003975-23)).
He has created a prediction model for aneuploidy in early embryo development revealed by single-cell analysis (PMID: 26151134), deciphered the clinical impact of embryo mosaicism (PMCID: PMC8715143), and discovered the origin, and composition of human embryo-cell free DNA (PMID: 29471395) and its clinical translation (PMID: 32470458)). His team derived, characterized, and registered 10 human embryonic stem cell lines in the Spanish National Stem Cell Bank. (PMID: 20018958). This work made possible the creation of the Valencia Node of the Spanish Stem Cell Bank. Finally, the cross-communication between maternal endometrium and the embryo (PMID: 29390102) has been addressed by discovering that maternal microRNAs (miRNAs) that might act as transcriptomic modifier of the pre-implantation embryo (PMID: 26395145).
He has published 538 papers articles (Pubmed). His papers have received a total of 50,121 citations. His Google Scholar is 127. He is editor of 22 books, and supervisor of 41 PhD Thesis. He has been awarded by several scientific societies including SGI/SRI and institutions including the Rey Jaime I Medical Research Award 2011, the ASRM Distinguished Research Award 2016, and the Lilly Foundation Biomedical Research Award 2021.
